Elucidating the mechanism of cellular
Student researchers will contribute to the scientific goals related to cell division while receiving a comprehensive training experience. These results demonstrate that this approach will provide an excellent framework for future detailed analysis of the CSC. Analysis of purified CESA complex and crude extracts suggests that disulfide bonds and noncovalent interactions contribute to the stability of the CESA subunit interactions. How does an individual cell know where to physically separate into two new cells? Section solely to indicate this fact.
Revision received November 17, In fission yeast, a conserved scaffolding protein called Mid1 is a foundational part of the contractile ring, functioning as the initial organizer to anchor the structure to the cell membrane and to recruit essential cytokinetic proteins to the cell division site. Because fission yeast Schizosaccharomyces pombe cells utilize evolutionarily conserved machinery during this process, they are an ideal model system to reveal general cell division properties. The practical skills gained will include creative problem solving, proper laboratory technique, clear oral and written communication, hypothesis development, and experimental design. This suggests that the three different CESA proteins undergo dimerization independently, but the presence of all three subunits is required for higher order oligomerization. Please report errors in award information by writing to: The costs of publication of this article were defrayed in part by the payment of page charges. Temporally and spatially organizing such a large assortment of proteins at the cellular division site requires precise regulatory mechanisms. No additional CESA isoforms or other proteins were identified. Given that Mid1 is functionally similar to anillin, a scaffolding protein required for cytokinesis in animal cells, a detailed study of the Mid1 scaffolding function is at the core of understanding cytokinesis in other biological systems. Proteins that are essential for physically dividing the cell undergo dynamic rearrangements within the cell to concentrate at the future site of cell division and coalesce into a ring structure called the contractile ring. Student researchers will contribute to the scientific goals related to cell division while receiving a comprehensive training experience. Cell division is a fundamental biological event that underlies the growth and development of all organisms. Received September 25, How does an individual cell know where to physically separate into two new cells? The broad questions addressed through this research are universal to cell division in all biological systems. With this approach, we used a two-step purification that preferentially selected for larger CESA oligomers. The research will characterize Mid1 interactions with other cytokinetic proteins and the cell membrane to elucidate a molecular model for bridging the cell division machinery to the cell membrane. Results will be disseminated in peer-reviewed journals, and undergraduate researchers will present their findings at regional and national scientific meetings. Cell and molecular biology majors at GVSU are among the top in the country with consistently high scores on standardized tests in this area. Preliminary results generated by student researchers suggest that Mid1 directly associates with multiple cytokinetic ring proteins and utilizes an enzyme-dependent mechanism to interact with the cell membrane. When is an appropriate time for a cell to divide? Like many of the students at GVSU, the principal investigator is a first-generation college graduate herself. Despite its importance, this goal remains elusive. The educational goals of this research project will positively impact students who are committed to long-term scientific careers and will further intensify the research atmosphere at GVSU.
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